BDBM257394 US9493441, 1-5

SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C(=O)N1CCS(=O)(=O)CC1)C(CC#N)C1CCCC1

InChI Key InChIKey=JXMOPXVHGJNIFF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 257394   

TargetGlutathione S-transferase P/Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM257394(US9493441, 1-5)
Affinity DataIC50:  31nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutathione S-transferase P/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM257394(US9493441, 1-5)
Affinity DataIC50:  9nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent