BindingDB BDBM25761 Anapriline::Avlocardyl::CHEMBL27::PROPANOLOL(-)::PROPRANOLOL, d::PROPRANOLOL, l-::PROPRANOLOL,(+)::PROPRANOLOL,(-)::Propanolol::Propanolol,(+/-)::Propranolol::[2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine

BDBM25761 Anapriline::Avlocardyl::CHEMBL27::PROPANOLOL(-)::PROPRANOLOL, d::PROPRANOLOL, l-::PROPRANOLOL,(+)::PROPRANOLOL,(-)::Propanolol::Propanolol,(+/-)::Propranolol::[2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine

SMILES CC(C)NCC(O)COc1cccc2ccccc12

InChI Key InChIKey=AQHHHDLHHXJYJD-UHFFFAOYSA-N

Data 81 KI 59 IC50 34 Kd 26 EC50

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 25761

Adenosine receptor A2a(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type A2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as cAMP by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University Of Alberta

Curated by PDSP K_i Database

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type M2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Delta-type opioid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type opioid-delta 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Type-1 angiotensin II receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type AGTR1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type M1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type 5-HT7 receptor expressed in HEK cells assessed as cAMP by HTRF assayMore data for this Ligand-Target Pair

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Adenosine receptor A3(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type A3 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Alpha-1A adrenergic receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type alpha 1A receptor expressed in CHO cells assessed as calcium level by HTRF assayMore data for this Ligand-Target Pair

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Alpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type alpha 2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Alpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Vasopressin V1a receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type AVPR1A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Cholecystokinin receptor type A(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type CCKA receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M3(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type M3 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Endothelin-1 receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as calcium level by HTRF assayMore data for this Ligand-Target Pair

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Kappa-type opioid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type opioid-kappa 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type D2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Mu-type opioid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type opioid-mu receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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D(1A) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type D1 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Nuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: 3.20E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair

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Nuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: 3.20E+4nMAssay Description:Agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as dec...More data for this Ligand-Target Pair

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Nuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL

PNG

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: 3.70E+4nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair

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Filter my 200 hits

Targets 54▿
- Beta-2 adrenergic receptor 34
- Beta-1 adrenergic receptor 27
- 5-hydroxytryptamine receptor 1B 16
- D(2) dopamine receptor 7
- Beta-1/Beta-2/Beta-3 adrenergic receptor 6
- Albumin 6
- 5-hydroxytryptamine receptor 1A 6
- D(1A) dopamine receptor 5
- Voltage-dependent L-type calcium channel subunit alpha-1C 5
- Bile salt export pump 5
- Alpha-2C adrenergic receptor 4
- Alpha-1A adrenergic receptor 4
- Beta-3 adrenergic receptor 4
- Nuclear receptor subfamily 2 group E member 1 4
- 5-hydroxytryptamine receptor 2C 4
- 5-hydroxytryptamine receptor 7 4
- 5-hydroxytryptamine receptor 2A 3
- 5-hydroxytryptamine receptor 6 3
- Vasopressin V1a receptor 2
- Endothelin-1 receptor 2
- 5-hydroxytryptamine receptor 5A 2
- Muscarinic acetylcholine receptor M3 2
- Cholecystokinin receptor type A 2
- Muscarinic acetylcholine receptor M2 2
- Muscarinic acetylcholine receptor M1 2
- ATP-dependent translocase ABCB1 2
- Type-1 angiotensin II receptor 2
- Kappa-type opioid receptor 2
- Adenosine receptor A3 2
- 5-hydroxytryptamine receptor 2B 2
- Delta-type opioid receptor 2
- Cytochrome P450 2D6 2
- Mu-type opioid receptor 2
- Alpha-2A adrenergic receptor 2
- Adenosine receptor A2a 2
- Sodium-dependent serotonin transporter 1
- Solute carrier family 22 member 1 1
- 5-hydroxytryptamine receptor 5B 1
- Cytochrome P450 2J2 1
- Potassium voltage-gated channel subfamily H member 2 1
- Sodium channel protein type 5 subunit alpha 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- ATP-binding cassette sub-family C member 2 1
- Cytochrome P450 1A2 1
- D(3) dopamine receptor 1
- Sodium/bile acid cotransporter 1
- Histamine H1 receptor 1
- Cytochrome P450 2C9 1
- 5-hydroxytryptamine receptor 3A 1
- Cytochrome P450 2C19 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Cytochrome P450 2C8 1
- Cytochrome P450 3A4 1
- ...
Publications 50▿
- J Med Chem 58: 9287-95 (2015) 55
- Neuropharmacology 33: 275-317 (1994) 8
- J Med Chem 54: 6874-87 (2011) 7
- NIDA Res Monogr 178: 440-66 (1998) 6
- Jpn J Pharmacol 52: 195-200 (1990) 6
- J Pharmacol Exp Ther 270: 665-74 (1994) 6
- J Med Chem 51: 2009-17 (2008) 6
- J Med Chem 59: 5780-9 (2016) 4
- Toxicol Sci 136: 216-41 (2013) 4
- J Med Chem 64: 8727-8738 (2021) 4
- J Med Chem 32: 859-63 (1989) 3
- Naunyn Schmiedebergs Arch Pharmacol 369: 151-9 (2004) 3
- J Med Chem 33: 2883-91 (1990) 3
- Bioorg Med Chem 27: 2959-2971 (2019) 3
- Br J Pharmacol 144: 317-22 (2005) 3
- Cardiovasc Res 91: 53-61 (2011) 3
- J Med Chem 36: 3077-86 (1993) 2
- Psychopharmacology (Berl) 124: 57-73 (1996) 2
- J Med Chem 27: 1291-4 (1984) 2
- Mol Pharmacol 12: 568-80 (1976) 2
- J Med Chem 63: 8458-8470 (2020) 2
- Mol Pharmacol 13: 454-73 (1977) 2
- Bioorg Med Chem 22: 234-46 (2014) 2
- J Med Chem 45: 5671-86 (2002) 2
- J Med Chem 61: 5380-5394 (2018) 2
- Life Sci 19: 69-76 (1976) 2
- Drug Metab Dispos 40: 130-8 (2011) 2
- J Pharmacol Exp Ther 253: 461-5 (1990) 2
- Mol Pharmacol 43: 313-9 (1993) 2
- J Med Chem 25: 1408-12 (1983) 2
- J Med Chem 27: 857-61 (1984) 2
- J Med Chem 26: 950-7 (1983) 2
- J Appl Toxicol 32: 858-66 (2012) 2
- J Med Chem 24: 994-8 (1982) 2
- J Pharmacol Exp Ther 241: 1092-8 (1987) 2
- Mol Pharmacol 12: 800-12 (1976) 2
- J Med Chem 23: 620-4 (1980) 2
- EMBO J 11: 4779-86 (1992) 1
- J Med Chem 36: 3161-5 (1993) 1
- J Med Chem 40: 4415-9 (1998) 1
- J Pharmacol Exp Ther 291: 1204-9 (1999) 1
- J Med Chem 30: 788-92 (1987) 1
- J Med Chem 32: 183-92 (1989) 1
- Medicinal Chemistry Research 17: 507-514 (2008) 1
- J Med Chem 33: 171-8 (1990) 1
- J Pharmacol Exp Ther 247: 169-73 (1988) 1
- Neuropsychopharmacology 3: 349-60 (1990) 1
- Brain Res 304: 1-7 (1984) 1
- Biochem Biophys Res Commun 184: 752-9 (1992) 1
- Bioorg Med Chem Lett 15: 3816-20 (2005) 1
- ...
Institutions 37▿
- Janssen Pharmaceutica 55
- TBA 21
- University Of Nottingham 10
- University Of Alberta 8
- Ohio State University 6
- Sri International 6
- Niigata College Of Pharmacy 6
- Universitat De Barcelona 6
- Novartis Institutes For Biomedical Research 4
- Amgen 4
- Goethe-University Frankfurt 4
- Virginia Commonwealth University 3
- Berlex Laboratories 3
- University Of Oxford 3
- UniversitÄT WÜRzburg 3
- Cnrs 3
- Friedrich-Alexander Universit£T Erlangen-N£Rnberg 3
- Marion Merrell Dow 2
- Astrazeneca 2
- Institute For Advanced Chemistry Of Catalonia (Iqac-Csic) 2
- Jagiellonian University 2
- University Of Florence 2
- University Of Pennsylvania 2
- Bulgarian Academy Of Sciences 2
- University Of California 2
- Medical University Of Lublin 2
- Universit£ 2
- Janssen Research Foundation 2
- Vanderbilt University School Of Medicine 1
- Sorbonne University 1
- Mayo Foundation 1
- Veterans Affairs Medical Center 1
- Medical College Of Virginia/Virginia Commonwealth University 1
- Pennwalt 1
- Bristol-Myers Squibb Pharmaceutical Research Institute 1
- The Medical University Of Warsaw 1
- Vanderbilt University 1
- ...
Affinity: 0.010 to 1.0E+6 nM▿
- Ki 81
- IC50 59
- Kd 34
- EC50 26
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1