BDBM2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US20240002365, Compound staurosporine::US9206188, Staurosporine::US9226923, Staurosporine
SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
InChI Key InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 872 hits for monomerid = 2579
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Mrc
Mrc
Affinity DataIC50: 9.00E+3nM Kd: 290nMpH: 7.2 T: 2°CAssay Description:Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre Of The Max Planck Society
Chemical Genomics Centre Of The Max Planck Society
Affinity DataIC50: 6.30nM Kd: 8nMAssay Description:Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.More data for this Ligand-Target Pair
Affinity DataKd: 1.40nMAssay Description:Binding affinity to non phosphorylated PIM1More data for this Ligand-Target Pair
Affinity DataKd: 710nMAssay Description:Average Binding Constant for BTK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 26nMAssay Description:Average Binding Constant for MAP4K5; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Average Binding Constant for ULK3 m; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 0.5nMAssay Description:Average Binding Constant for PHkg1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 9nMAssay Description:Average Binding Constant for PRKAA1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 160nMAssay Description:Average Binding Constant for ABL2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 1.40E+3nMAssay Description:Average Binding Constant for CSNK1G2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 30nMAssay Description:Average Binding Constant for CAMK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 340nMAssay Description:Average Binding Constant for JNK3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 8.10nMAssay Description:Average Binding Constant for CDK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 240nMAssay Description:Average Binding Constant for EPHA6; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 2.90E+3nMAssay Description:Average Binding Constant for STK36; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 70nMAssay Description:Average Binding Constant for EGFR; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 100nMAssay Description:Average Binding Constant for KIT; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 340nMAssay Description:Average Binding Constant for ABL1(H396P) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 7nMAssay Description:Average Binding Constant for SYK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 240nMAssay Description:Average Binding Constant for TEK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Average Binding Constant for PIM1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 200nMAssay Description:Average Binding Constant for STK16; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 2nMAssay Description:Average Binding Constant for CAMK1D; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 1.30nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 870nMAssay Description:Average Binding Constant for EPHA2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 25nMAssay Description:Average Binding Constant for PCTK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 0.0500nMAssay Description:Average Binding Constant for CAMKK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 3.50E+3nMAssay Description:Average Binding Constant for CLK3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Average Binding Constant for EPHA5; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 60nMAssay Description:Average Binding Constant for RPS6KA3 (Kin.Dom. 1); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 20nMAssay Description:Average Binding Constant for LCK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Average Binding Constant for SRC; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 170nMAssay Description:Average Binding Constant for ABL1(Y253F); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 2nMAssay Description:Average Binding Constant for PAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 38nMAssay Description:Average Binding Constant for ABL1(T315I) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 0.5nMAssay Description:Average Binding Constant for PAK3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Average Binding Constant for RPS6KA2 (Kin.Dom. 1); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 49nMAssay Description:Average Binding Constant for YES; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 89nMAssay Description:Average Binding Constant for CDK5; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetSTE20-like serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 0.0200nMAssay Description:Average Binding Constant for SLK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1G(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 53nMAssay Description:Average Binding Constant for CAMK1G; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 0.0500nMAssay Description:Average Binding Constant for CAMKK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 4nMAssay Description:Average Binding Constant for PIM2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 410nMAssay Description:Average Binding Constant for ABL1 ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 51nMAssay Description:Average Binding Constant for FYN; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 690nMAssay Description:Average Binding Constant for CSNK1E; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit beta(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 3nMAssay Description:Average Binding Constant for CAMK2B; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Average Binding Constant for PRKACA; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 0.100nMAssay Description:Average Binding Constant for MARK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 2579
ITC DataΔG°: -11.5kcal/mole −TΔS°: -3.33kcal/mole ΔH°: -8.09kcal/mole logk: 7.05E+8
pH: 7.5 T: 10.00°C
pH: 7.5 T: 10.00°C