BDBM264119 3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl)piperazin-1-yl)propyl)-1H-indole-5-carbonitrile::US9714232, 32
SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
InChI Key InChIKey=QGUBOPJCHFVENQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 264119
Affinity DataKi: 1.70nMpH: 7.4Assay Description:Human HEK-293 cell homogenates (36 μg protein) were incubated at 22° C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Sunshine Lake Pharma
Curated by ChEMBL
Sunshine Lake Pharma
Curated by ChEMBL
Affinity DataIC50: 0.930nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-HT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-HT2a (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-HT2c (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.930nMpH: 7.4Assay Description:The synaptosomes (150 μg) prepared from a rat brain were incubated at 37° C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of 5-HT1a (unknown origin)More data for this Ligand-Target Pair