BDBM264119 3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl)piperazin-1-yl)propyl)-1H-indole-5-carbonitrile::US9714232, 32

SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1

InChI Key InChIKey=QGUBOPJCHFVENQ-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 264119   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataKi:  1.70nMpH: 7.4Assay Description:Human HEK-293 cell homogenates (36 μg protein) were incubated at 22° C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-HT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-HT2a (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-HT2c (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50:  0.930nMpH: 7.4Assay Description:The synaptosomes (150 μg) prepared from a rat brain were incubated at 37° C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of 5-HT1a (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed