BDBM26668 CHEMBL494360::N-cyclohexyl-3-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[3,4-a]pyridin-6-amine::triazolopyridazine compound, 1

SMILES FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CCCCC3)nn12

InChI Key InChIKey=XYYDXQCAYXOGQT-UHFFFAOYSA-N

Data  2 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26668   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26668(CHEMBL494360 | N-cyclohexyl-3-[3-(trifluoromethyl)...)
Affinity DataKi:  11nMAssay Description:Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26668(CHEMBL494360 | N-cyclohexyl-3-[3-(trifluoromethyl)...)
Affinity DataKi:  11nM ΔG°:  -11.0kcal/molepH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed