BDBM278589 (2E)-3-(1-{[5-(1,1- Difluoroethyl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 51

SMILES Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12

InChI Key InChIKey=BOOMBLZEOHXPPX-BQYQJAHWSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278589   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278589((2E)-3-(1-{[5-(1,1- Difluoroethyl)-3-(2,4,6- trich...)
Affinity DataIC50:  115nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278589((2E)-3-(1-{[5-(1,1- Difluoroethyl)-3-(2,4,6- trich...)
Affinity DataIC50:  15nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair