BDBM278613 (2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(3- methyloxetan-3-yl)-1,2-oxazol- 4-yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 75

SMILES CC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl

InChI Key InChIKey=JNJIAVNFRMJGQU-CMDGGOBGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278613   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278613((2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(3- methylox...)
Affinity DataIC50:  118nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278613((2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(3- methylox...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent