BDBM284965 N-ethyl-3-(2-methyl-1-oxo-isoquinolin-4-yl) benzenesulfonamide::US10023592, Example 10

SMILES CCNS(=O)(=O)c1cccc(c1)-c1cn(C)c(=O)c2ccccc12

InChI Key InChIKey=NUSJWFJNHMHOIW-UHFFFAOYSA-N

Data  2 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 284965   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM284965(N-ethyl-3-(2-methyl-1-oxo-isoquinolin-4-yl) benzen...)
Show SMILES CCNS(=O)(=O)c1cccc(c1)-c1cn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C18H18N2O3S/c1-3-19-24(22,23)14-8-6-7-13(11-14)17-12-20(2)18(21)16-10-5-4-9-15(16)17/h4-12,19H,3H2,1-2H3
Affinity DataIC50: 710nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM284965(N-ethyl-3-(2-methyl-1-oxo-isoquinolin-4-yl) benzen...)
Show SMILES CCNS(=O)(=O)c1cccc(c1)-c1cn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C18H18N2O3S/c1-3-19-24(22,23)14-8-6-7-13(11-14)17-12-20(2)18(21)16-10-5-4-9-15(16)17/h4-12,19H,3H2,1-2H3
Affinity DataIC50: 2.75E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid