BDBM285022 2-methyl-4-(1,3-oxazol-2-yl)isoquinolin- 1-one::US10023592, Example 67::US10941160, Example 67

SMILES Cn1cc(-c2ncco2)c2ccccc2c1=O

InChI Key InChIKey=VYVPGIUGYNRIJA-UHFFFAOYSA-N

Data  3 IC50

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 285022   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research Inc

US Patent
LigandPNGBDBM285022(2-methyl-4-(1,3-oxazol-2-yl)isoquinolin- 1-one | U...)
Show SMILES Cn1cc(-c2ncco2)c2ccccc2c1=O
Show InChI InChI=1S/C13H10N2O2/c1-15-8-11(12-14-6-7-17-12)9-4-2-3-5-10(9)13(15)16/h2-8H,1H3
Affinity DataIC50: 5.00E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research Inc

US Patent
LigandPNGBDBM285022(2-methyl-4-(1,3-oxazol-2-yl)isoquinolin- 1-one | U...)
Show SMILES Cn1cc(-c2ncco2)c2ccccc2c1=O
Show InChI InChI=1S/C13H10N2O2/c1-15-8-11(12-14-6-7-17-12)9-4-2-3-5-10(9)13(15)16/h2-8H,1H3
Affinity DataIC50: 5.00E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research Inc

US Patent
LigandPNGBDBM285022(2-methyl-4-(1,3-oxazol-2-yl)isoquinolin- 1-one | U...)
Show SMILES Cn1cc(-c2ncco2)c2ccccc2c1=O
Show InChI InChI=1S/C13H10N2O2/c1-15-8-11(12-14-6-7-17-12)9-4-2-3-5-10(9)13(15)16/h2-8H,1H3
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid