BDBM285026 2-methyl-4-pyrimidin-2-ylisoquinolin- 1-one::US10023592, Example 71::US10941160, Example 71
SMILES Cn1cc(-c2ncccn2)c2ccccc2c1=O
InChI Key InChIKey=NKFXHORUAWERQK-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 285026
Affinity DataIC50: >5.00E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair