BDBM294303 US9586948, Example 22

SMILES Cn1cc(NC(=O)c2cccc(n2)-c2ccsc2)c(n1)C(N)=O

InChI Key InChIKey=SGPNWUYYNYULHU-UHFFFAOYSA-N

Data  3 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 294303   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM294303(US9586948, Example 22)
Show SMILES Cn1cc(NC(=O)c2cccc(n2)-c2ccsc2)c(n1)C(N)=O
Show InChI InChI=1S/C15H13N5O2S/c1-20-7-12(13(19-20)14(16)21)18-15(22)11-4-2-3-10(17-11)9-5-6-23-8-9/h2-8H,1H3,(H2,16,21)(H,18,22)
Affinity DataIC50: 362nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid