BDBM304636 (S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((1s,4R)-4-(trifluoromethyl)cyclohexyl)methyl)piperazine::US10144715, Compound 48-31

SMILES CS(=O)(=O)c1cccc(c1)N1CCN([C@H](C1)c1ccccc1)C(=O)C1CC[C@@H](CC1)C(F)(F)F

InChI Key InChIKey=UKPWIODZPKIVBB-CXAYOUKQSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 304636   

TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304636((S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((1s,...)
Affinity DataKi:  5nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304636((S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((1s,...)
Affinity DataKi:  42nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304636((S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((1s,...)
Affinity DataEC50:  22nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304636((S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((1s,...)
Affinity DataEC50:  401nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent