BDBM317196 3,8-Dimethyl-6-((1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)ethynyl)-2-(trifluoro-methyl)imidazo[1,2-b]pyridazine::Roche-Dataset for PDE10A, Compound 138::US9617271, 54

SMILES Cc1c(nc2c(C)cc(nn12)C#Cc1nc(nn1C)N1CCCC1)C(F)(F)F

InChI Key InChIKey=PPPPMCPCFDIGGO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317196   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM317196(3,8-Dimethyl-6-((1-methyl-3-(pyrrolidin-1-yl)-1H-1...)
Affinity DataIC50:  0.640nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM317196(3,8-Dimethyl-6-((1-methyl-3-(pyrrolidin-1-yl)-1H-1...)
Affinity DataIC50:  1.60nMAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent