BDBM31768 CHEMBL295698::Ketoconazole::Nizoral::Panfungol
SMILES CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
InChI Key InChIKey=XMAYWYJOQHXEEK-ZEQKJWHPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 31768
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Syntex Discovery Research
Curated by ChEMBL
Syntex Discovery Research
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reduc...More data for this Ligand-Target Pair
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataKi: 35nMAssay Description:Inhibition of N-terminally MBP-fused human CYP24A1 by cell-free assayMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of Maryland
Curated by ChEMBL
University Of Maryland
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of Maryland
Curated by ChEMBL
University Of Maryland
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)More data for this Ligand-Target Pair
Target25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Mus musculus)
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataKi: 58nMAssay Description:Inhibition of mouse CYP27B1 using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reductase and NADPH incubated at 37 degC for 2...More data for this Ligand-Target Pair
Target25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Mus musculus)
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataKi: 58nMAssay Description:Inhibition of mouse CYP27B1 by cell-free assayMore data for this Ligand-Target Pair
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Syntex Discovery Research
Curated by ChEMBL
Syntex Discovery Research
Curated by ChEMBL
Affinity DataKi: 64nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
Affinity DataKi: 65nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase of rat hepatic microsomesMore data for this Ligand-Target Pair
Affinity DataKi: 398nMAssay Description:Inhibition of human recombinant aromatase assessed as conversion of O-dibenzylfluorescein benzyl ester substrate to fluorescein byproduct by fluorome...More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Inhibition of human recombinant aromatase assessed as conversion of O-dibenzylfluorescein benzyl ester substrate to fluorescein byproduct by fluorome...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 5.27E+3nMAssay Description:TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 2.49E+4nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6.50E+4nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair