BDBM31886 CD564::CHEMBL309282

SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)c1ccc2cc(ccc2c1)C(O)=O

InChI Key InChIKey=RWYREGSYPCNZTL-UHFFFAOYSA-N

Data  2 IC50  6 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 31886   

LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataKd:  3nMpH: 7.9 T: 4°CAssay Description:Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataKd:  118nMpH: 7.9 T: 4°CAssay Description:Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataKd:  1.20nMpH: 7.9 T: 4°CAssay Description:Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCytochrome P450 26B1(Human)
The University of Montana

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataIC50:  520nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor gamma(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataKd:  3nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetRetinoic acid receptor beta(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataKd:  1.20nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetCytochrome P450 26A1(Human)
The University of Montana

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor alpha(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataKd:  118nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed