BDBM320690 (R)- or (S)-6-(Dimethylamino)-1-(1- (3-fluoro-4-(2,2,2- trifluoroethyl)phenyl)propyl)-3- (hydroxymethyl)-1H-pyrazolo[3,4- d]pyrimidin-4(5H)-one::US10174037, Example 96::US10174037, Example 97

SMILES CCC(c1ccc(CC(F)(F)F)c(F)c1)n1nc(CO)c2c1nc([nH]c2=O)N(C)C

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320690   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320690((R)- or (S)-6-(Dimethylamino)-1-(1- (3-fluoro-4-(2...)
Affinity DataKi:  0.0900nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320690((R)- or (S)-6-(Dimethylamino)-1-(1- (3-fluoro-4-(2...)
Affinity DataKi:  0.110nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320690((R)- or (S)-6-(Dimethylamino)-1-(1- (3-fluoro-4-(2...)
Affinity DataKi:  0.320nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320690((R)- or (S)-6-(Dimethylamino)-1-(1- (3-fluoro-4-(2...)
Affinity DataKi:  0.5nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent