BDBM320774 (R)- or (S)-1-(Cyclopropyl(3-fluoro-4- (trifluoromethyl)phenyl)methyl)-6- (dimethylamino)-3-(fluoromethyl)-1H- pyrazolo[3,4-d]pyrimidin-4(5H)-one::US10174037, Example 180::US10174037, Example 181

SMILES CN(C)c1nc2n(nc(CF)c2c(=O)[nH]1)C(C1CC1)c1ccc(c(F)c1)C(F)(F)F

InChI Key

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 320774   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320774((R)- or (S)-1-(Cyclopropyl(3-fluoro-4- (trifluorom...)
Affinity DataKi:  0.0580nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320774((R)- or (S)-1-(Cyclopropyl(3-fluoro-4- (trifluorom...)
Affinity DataKi:  0.110nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320774((R)- or (S)-1-(Cyclopropyl(3-fluoro-4- (trifluorom...)
Affinity DataKi:  1.20nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent