BDBM339054 US10201546, Example 14a
SMILES COc1nc2ccc(cc2c(Cl)c1CC1CC1)C(O)(c1cnnn1C)c1ccc(C)nc1C
InChI Key InChIKey=DXXBABLKRGNIHP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 339054
Affinity DataKd: 2.5nMAssay Description:ThermoFluor is a fluorescence based assay that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal stability (...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Affinity DataKd: 1.30nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair