BDBM35254 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine::CHEMBL715::Olansek::US8802672, Olanzapine::Zyprexa::olanzapine

SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(C)cc12

InChI Key InChIKey=KVWDHTXUZHCGIO-UHFFFAOYSA-N

Data  180 KI  19 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 35254   

TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Richter Gedeon

US Patent
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  25.1nMAssay Description:Alpha-1 receptor binding studies were performed according to the methods described by Greengrass and Bremner (Eur. J. Pharmacol., 55:323-326, 1979) o...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Richter Gedeon

US Patent
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  76nMAssay Description:Binding assays were carried out on rat recombinant D3 receptors (Perkin-Elmer, Cat. No. 6110139) expressed in Sf9 cells using [3H]spiperone (0.44-1.4...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Richter Gedeon

US Patent
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  96nMAssay Description:D2 receptor binding was determined as described by Creese et al. (Eur. J. Pharmacol., 60:55-66, 1979) on rat brain striatal membrane preparation usin...More data for this Ligand-Target Pair
In DepthDetails US Patent