BDBM35646 erk000506::pyrimidylpyrrole, 9e

SMILES Cc1cnc(Nc2ccccc2C(F)(F)F)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1

InChI Key InChIKey=YCXYNILFCBIHHV-OAQYLSRUSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 35646   

TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35646(erk000506 | pyrimidylpyrrole, 9e)
Affinity DataKi:  4nM ΔG°:  -11.6kcal/molepH: 7.5 T: 30°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35646(erk000506 | pyrimidylpyrrole, 9e)
Affinity DataKi:  4nMAssay Description:Photometric_Method2More data for this Ligand-Target Pair
In DepthDetails D3R

TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35646(erk000506 | pyrimidylpyrrole, 9e)
Affinity DataKi:  4nMAssay Description:Assay 1 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35646(erk000506 | pyrimidylpyrrole, 9e)
Affinity DataKi: >800nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35646(erk000506 | pyrimidylpyrrole, 9e)
Affinity DataKi:  2.30E+3nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35646(erk000506 | pyrimidylpyrrole, 9e)
Affinity DataKi: >4.00E+3nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed