BDBM35657 pyrimidylpyrrole, 11e

SMILES Cc1cnc(Nc2ccc(F)cc2Cl)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1cccc(Cl)c1

InChI Key InChIKey=WUTVMXLIGHTZJC-OAQYLSRUSA-N

Data  4 KI

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 35657   

TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35657(pyrimidylpyrrole, 11e)
Affinity DataKi: <2nM ΔG°: <-12.1kcal/molepH: 7.5 T: 30°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35657(pyrimidylpyrrole, 11e)
Affinity DataKi:  395nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35657(pyrimidylpyrrole, 11e)
Affinity DataKi:  540nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35657(pyrimidylpyrrole, 11e)
Affinity DataKi:  852nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed