BDBM384949 N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl]propyl}-2- [(3S)-3-fluoropyrrolidin-1-yl]-6- oxo-1,6-dihydropyrimidine-4- carboxamide::US10285989, Example 169

SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N1CC[C@H](F)C1)c1ccc(cc1)C(F)(F)F

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384949   

TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384949(N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...)
Affinity DataKi:  0.140nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384949(N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...)
Affinity DataKi:  0.170nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent