BDBM396758 6-(5'-fluoro-6'-methyl-[2,2'-bipyridin]-3- yl)pyrido[3,2-d]pyrimidin-4-amine::US9981944, Example 103

SMILES Cc1nc(ccc1F)-c1ncccc1-c1ccc2ncnc(N)c2n1

InChI Key InChIKey=XVBKGEJGVAOOOM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 396758   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396758(6-(5'-fluoro-6'-methyl-[2,2'-bipyridin]-3- yl)pyri...)
Affinity DataIC50: >1.50E+4nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [T204D](Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396758(6-(5'-fluoro-6'-methyl-[2,2'-bipyridin]-3- yl)pyri...)
Affinity DataIC50:  4nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent