BDBM396775 5-(6'-methyl-[2,2'-bipyridin]-3- yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::US9981944, Example 120

SMILES Cc1cccc(n1)-c1ncccc1-c1ccn2ncc(C(N)=O)c2n1

InChI Key InChIKey=HKNCTBCYPOKHHS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 396775   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396775(5-(6'-methyl-[2,2'-bipyridin]-3- yl)pyrazolo[1,5-a...)
Affinity DataIC50: >1.50E+4nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [T204D](Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396775(5-(6'-methyl-[2,2'-bipyridin]-3- yl)pyrazolo[1,5-a...)
Affinity DataIC50:  6nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent