BDBM405274 1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)methyl)-5-(6-methoxypyridazin-3-yl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)phenyl)-3-methoxyurea::US10344034, Example 11::US10633388, Example 11

SMILES CONC(=O)Nc1ccc(cc1)-n1nc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(OC)nn3)c(=O)c2c1CN(C)C

InChI Key InChIKey=IMJPTZZFUZNJLV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 405274   

TargetGonadotropin-releasing hormone receptor(Rabbit)
Shanghai Hengrui Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 405274BDBM405274(US10344034, Example 11 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 0.570nMAssay Description:In vitro GnRHr protein activity was tested by the following methods.This assay was used to determine the inhibition effect of the present compound on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetGonadotropin-releasing hormone II receptor(Green monkey)
Shanghai Hengrui Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 405274BDBM405274(US10344034, Example 11 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 0.570nMAssay Description:In vitro GnRHr protein activity was tested by the following methods.This assay was used to determine the inhibition effect of the present compound on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 405274BDBM405274(US10344034, Example 11 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 4.95nMAssay Description:In vitro GnRHr protein activity was tested by the following methods.This assay was used to determine the inhibition effect of the present compound on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent