BDBM409006 US10377744, Compound No. 27::US11123311, Compound 27::US11723929, Compound 27

SMILES Fc1cc(NC(=O)NC2CCN(CC2)C(=O)C2CCCOC2)ccc1OC(F)(F)F

InChI Key InChIKey=DWZCARYLQUBAOL-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 409006   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409006(US10377744, Compound No. 27 | US11123311, Compound...)
Affinity DataKi:  0.780nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409006(US10377744, Compound No. 27 | US11123311, Compound...)
Affinity DataKi:  0.780nMAssay Description:Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409006(US10377744, Compound No. 27 | US11123311, Compound...)
Affinity DataKi:  0.780nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent