BDBM409028 US10377744, Compound No. 48::US11123311, Compound 48::US11723929, Compound 48

SMILES Fc1cc(NC(=O)CC2CCN(CC2)C(=O)C2CC2)ccc1OC(F)(F)F

InChI Key InChIKey=QYIMJHVKOIOUBM-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 409028   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409028(US10377744, Compound No. 48 | US11123311, Compound...)
Affinity DataKi:  6.60nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpoxide hydrolase 1(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM409028(US10377744, Compound No. 48 | US11123311, Compound...)
Affinity DataKi:  6.60nMAssay Description:Scores of sEH inhibitors are known, of a variety of chemical structures. Derivatives in which the urea, carbamate or amide pharmacophore are particul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409028(US10377744, Compound No. 48 | US11123311, Compound...)
Affinity DataKi:  6.60nMAssay Description:Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409028(US10377744, Compound No. 48 | US11123311, Compound...)
Affinity DataKi:  6.60nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent