BDBM416558 US10307425, Example 24::US10632122, Example 24

SMILES CC(C)(O)Cn1nc(-c2ccc3cc(OC4CC4)ccc3c2)c2c(N)ncnc12

InChI Key InChIKey=NYCAEKAKFOSFFT-UHFFFAOYSA-N

Data  5 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 416558   

TargetCAM kinase, CDPK family TgCDPK1(Toxoplasma gondii (strain ATCC 50861 / VEG))
University Of Washington

US Patent
LigandPNGBDBM416558(US10307425, Example 24 | US10632122, Example 24)
Affinity DataIC50:  1nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

US Patent
LigandPNGBDBM416558(US10307425, Example 24 | US10632122, Example 24)
Affinity DataIC50:  1nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM416558(US10307425, Example 24 | US10632122, Example 24)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of chicken Src using AcEIYGEFKKK as substrate after 90 mins in presence of ATP by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM416558(US10307425, Example 24 | US10632122, Example 24)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

US Patent
LigandPNGBDBM416558(US10307425, Example 24 | US10632122, Example 24)
Affinity DataEC50:  430nMAssay Description:Inhibition of wild type hemagglutinin-tagged Toxoplasma gondii RH CDPK1 assessed as parasite growth inhibition infected in human foreskin fibroblasts...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

US Patent
LigandPNGBDBM416558(US10307425, Example 24 | US10632122, Example 24)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB