BDBM422171 2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-(4- methylbenzenesulfonyl)- 1,4-dihydropyrimidin- 4-one::US10508104, Example 62::US10508104, Example 66

SMILES CCCCc1nc(=O)c(c(O)n1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(C)cc1

InChI Key InChIKey=BLGNPGSXHWXDOA-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 422171   

TargetApelin receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422171(2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-(4- ...)
Affinity DataEC50:  5nMAssay Description:HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422171(2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-(4- ...)
Affinity DataEC50:  5nMAssay Description:HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422171(2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-(4- ...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetApelin receptor(Rattus norvegicus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422171(2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-(4- ...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422171(2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-(4- ...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed