BDBM444483 US10662186, Compound 9::US10988476, Compound I-9

SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CCO)ncc1F

InChI Key InChIKey=JDIAYVMOUUKPNK-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 444483   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  1.74nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  7.09nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  13.4nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  62.2nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  1.32E+4nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  7.52nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  1.74nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  7.09nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  13.4nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  62.2nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  1.32E+4nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444483(US10662186, Compound 9 | US10988476, Compound I-9)
Affinity DataIC50:  7.52nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent