BDBM453551 4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4- oxobutanoic acid::US10730849, Example 16
SMILES COc1cc2cc(sc2cc1OC)C(=O)CCC(O)=O
InChI Key InChIKey=APCLRHPWFCQIMG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 453551
Affinity DataEC50: 1.72E+3nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 2.48E+3nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40E+4nMAssay Description:Agonist activity at wild type human STING expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 8.30E+3nMAssay Description:Agonist activity at human STING HAQ mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 1.72E+3nMAssay Description:Displacement of [3H]-cGAMP from full-length wild type human STING by filtration binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.51E+3nMAssay Description:Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human STING in STING knockout human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8.14E+3nMAssay Description:Agonist activity at STING in human THP1-Dual cells assessed as ISG pathway activation incubated for 24 hrs by Quanti-Luc or Quanti-blue reagent based...More data for this Ligand-Target Pair