BDBM467195 US10800783, Example 187::US11396512, Example 187

SMILES C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(N)(=O)=O)ncc2cc(C(F)F)c1=O

InChI Key InChIKey=WWYNWGGCJJEZAV-AUUYWEPGSA-N

Data  4 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 467195   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM467195(US10800783, Example 187 | US11396512, Example 187)
Show SMILES C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(N)(=O)=O)ncc2cc(C(F)F)c1=O
Show InChI InChI=1S/C19H26F2N6O4S/c1-19(29)6-2-3-14(19)27-16-11(9-13(15(20)21)17(27)28)10-23-18(25-16)24-12-4-7-26(8-5-12)32(22,30)31/h9-10,12,14-15,29H,2-8H2,1H3,(H2,22,30,31)(H,23,24,25)/t14-,19-/m1/s1
Affinity DataKi:  0.0800nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM467195(US10800783, Example 187 | US11396512, Example 187)
Show SMILES C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(N)(=O)=O)ncc2cc(C(F)F)c1=O
Show InChI InChI=1S/C19H26F2N6O4S/c1-19(29)6-2-3-14(19)27-16-11(9-13(15(20)21)17(27)28)10-23-18(25-16)24-12-4-7-26(8-5-12)32(22,30)31/h9-10,12,14-15,29H,2-8H2,1H3,(H2,22,30,31)(H,23,24,25)/t14-,19-/m1/s1
Affinity DataKi:  0.0800nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM467195(US10800783, Example 187 | US11396512, Example 187)
Show SMILES C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(N)(=O)=O)ncc2cc(C(F)F)c1=O
Show InChI InChI=1S/C19H26F2N6O4S/c1-19(29)6-2-3-14(19)27-16-11(9-13(15(20)21)17(27)28)10-23-18(25-16)24-12-4-7-26(8-5-12)32(22,30)31/h9-10,12,14-15,29H,2-8H2,1H3,(H2,22,30,31)(H,23,24,25)/t14-,19-/m1/s1
Affinity DataKi:  0.290nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM467195(US10800783, Example 187 | US11396512, Example 187)
Show SMILES C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(N)(=O)=O)ncc2cc(C(F)F)c1=O
Show InChI InChI=1S/C19H26F2N6O4S/c1-19(29)6-2-3-14(19)27-16-11(9-13(15(20)21)17(27)28)10-23-18(25-16)24-12-4-7-26(8-5-12)32(22,30)31/h9-10,12,14-15,29H,2-8H2,1H3,(H2,22,30,31)(H,23,24,25)/t14-,19-/m1/s1
Affinity DataKi:  0.290nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid