BDBM470688 2-fluoro-5-methyl-4-(methyl((S)-::US10815229, Example 109

SMILES CN([C@H]1CCN(C1)C1CC(C1)c1ccccc1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=CTHPLXSKXVTVMI-KBWCOIMZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 470688   

TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM470688(2-fluoro-5-methyl-4-(methyl((S)- | US10815229, Exa...)
Affinity DataIC50:  1.11E+3nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM470688(2-fluoro-5-methyl-4-(methyl((S)- | US10815229, Exa...)
Affinity DataIC50:  1.99E+3nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM470688(2-fluoro-5-methyl-4-(methyl((S)- | US10815229, Exa...)
Affinity DataIC50:  2.80E+3nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent