BDBM4818 5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-N-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrole-3-carboxamide::SU11248 analog 12f

SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NCCN1CCCC1

InChI Key InChIKey=SRSGVKWWVXWSJT-ATVHPVEESA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4818   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Sugen

LigandPNGBDBM4818(5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yli...)
Affinity DataIC50:  60nMpH: 7.5 T: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

LigandPNGBDBM4818(5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yli...)
Affinity DataIC50: >2.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

LigandPNGBDBM4818(5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yli...)
Affinity DataIC50:  1nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Sugen

LigandPNGBDBM4818(5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yli...)
Affinity DataIC50:  3.90E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed