BDBM481879 (4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl) amino)-3-methoxyphenyl)(morpholino)methanone ::US10913744, Compound 18

SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)nc2[nH]cc(Cl)c12

InChI Key InChIKey=HUEKBQXFNHWTQQ-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 481879   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM481879((4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  6.5nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,G2019S](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM481879((4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  2.20nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,G2019S](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM481879((4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  2.20nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T,G2019S](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM481879((4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  19.8nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM481879((4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  6.60nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM481879((4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  47.7nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent