BDBM482159 BDBM50401284::GSK2578215A

SMILES Fc1cc(ccn1)-c1ccc(OCc2ccccc2)c(c1)C(=O)Nc1cccnc1

InChI Key InChIKey=WCIGMFCFPXZRMQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 482159   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM482159(BDBM50401284 | GSK2578215A)
Affinity DataIC50:  10.9nMAssay Description:Inhibition of recombinant His6-Tev-tagged LRRK2 expressed in baculovirus assessed as inhibition of LRRKtide phospohorylation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM482159(BDBM50401284 | GSK2578215A)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM482159(BDBM50401284 | GSK2578215A)
Affinity DataIC50:  10nMAssay Description:Inhibition of LRRK2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T,G2019S](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482159(BDBM50401284 | GSK2578215A)
Affinity DataIC50:  61.3nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482159(BDBM50401284 | GSK2578215A)
Affinity DataIC50:  10.9nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482159(BDBM50401284 | GSK2578215A)
Affinity DataIC50:  81.1nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,G2019S](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482159(BDBM50401284 | GSK2578215A)
Affinity DataIC50:  8.90nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent