BDBM495012 US10994015, Example 308

SMILES CC(C)n1nc(N2CC(CNCCCOCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(cc3)-c3scnc3C)C(C)(C)C)C2)c2cnc(Nc3ccnc(n3)-c3cnn(c3)S(=O)(=O)C3CC3)cc12

InChI Key InChIKey=MZJKZDHUFICXGJ-XNQOUOMRSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 495012   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM495012(US10994015, Example 308)
Affinity DataIC50:  120nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-745,747-749,751-1210](Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM495012(US10994015, Example 308)
Affinity DataIC50:  53nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM495012(US10994015, Example 308)
Affinity DataIC50:  0.270nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM495012(US10994015, Example 308)
Affinity DataIC50:  0.910nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M](Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM495012(US10994015, Example 308)
Affinity DataIC50:  2.10nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent