BDBM50005579 CHEMBL139148::Obidoxime

SMILES O\N=C\c1cc[n+](COC[n+]2ccc(\C=N\O)cc2)cc1

InChI Key InChIKey=HIGRLDNHDGYWQJ-UHFFFAOYSA-P

Data  3 IC50  15 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50005579   

TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  5.40E+4nMAssay Description:Reactivation of methylphosphonothioate VX-inhibited recombinant human AChE measured up to 10 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  1.20E+3nMAssay Description:Reactivation of dichlorvos-inhibited human AChE assessed as dissociation constant incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  3.22E+4nMAssay Description:Reactivation of paraoxon-inhibited recombinant human AChE measured up to 10 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  1.44E+4nMAssay Description:Reactivation of VX-inhibited human acetylcholinesterase assessed as dissociation constant incubated for 60 mins using ATChI substrate by DTNB dye bas...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  1.95E+4nMAssay Description:Reactivation of sarin-inhibited human acetylcholinesterase assessed as dissociation constant incubated for 60 mins using ATChI substrate by DTNB dye ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  2.02E+4nMAssay Description:Reactivation of O-ethylsarin-inhibited human acetylcholinesterase assessed as dissociation constant incubated for 60 mins using ATChI substrate by DT...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataIC50:  2.17E+6nMAssay Description:Inhibition of human AChE using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition measured every 5 mins for 20 mi...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  5.00E+5nMAssay Description:Reactivation of NIMP-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mi...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  5.50E+5nMAssay Description:Reactivation of ethyl paraoxon-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataIC50:  6.40E+5nMAssay Description:Inhibition of human recombinant AChE by spectrophotometry based Ellman's assayMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  9.10E+4nMAssay Description:Reactivation of sarin-induced inhibition of human AChE assessed as dissociation constant using acetylthiocholine as substrate preincubated for 30 min...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataIC50:  2.17E+6nMAssay Description:Inhibition of human AChE assessed as decrease in enzyme activity incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  4.79E+4nMAssay Description:Reactivation of VX-inhibited human AChE assessed as dissociation constant incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  6.80E+3nMAssay Description:Reactivation of paraoxon-inhibited human AChE assessed as dissociation constant incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  9.17E+4nMAssay Description:Reactivation of tabun-inhibited human AChE assessed as dissociation constant incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  2.10E+3nMAssay Description:Reactivation of sarin-inhibited human AChE assessed as dissociation constant incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  5.30E+3nMAssay Description:Reactivation of parathion-inhibited human AChE assessed as dissociation constant incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  2.50E+5nMAssay Description:Reactivation of tabun-inhibited recombinant human AChE measured up to 10 mins by Ellman's methodMore data for this Ligand-Target Pair