BDBM50005711 CHEBI:46024::GNF-Pf-1011::TRICHOSTATIN::Trichostatin A::Trichostatin A (TSA)::US10011611, Trichostatin A::US10722597, Compound Trichostatin::US11535598, Compound Trichostatin A::US20230322747, Compound trichostatin A::US9265734, TSA
SMILES C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
InChI Key InChIKey=RTKIYFITIVXBLE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 361 hits for monomerid = 50005711
Affinity DataIC50: 6.70nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 14.8nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 9.60nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 34.8nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 12.5nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 197nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 165nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 70.1nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 22.8nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 5.22nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 11.5nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 5.58nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 70.1nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 3.23E+3nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 1.48E+3nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 2.95E+3nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 4.04E+3nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 1.22nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 18.3nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 12.3nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.41nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 213nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 871nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 663nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.721nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 11.6nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataKd: 12.1nMpH: 8.0Assay Description:Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD...More data for this Ligand-Target Pair
Affinity DataKd: 15.3nMpH: 8.0Assay Description:Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human HDAC3 complexed with NCOR2 using fluorogenic tetrapeptide RHKKAc as susbtrateMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human HDAC4 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of human HDAC9 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human HDAC1 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human HDAC11 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human HDAC5 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human HDAC7 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMAssay Description:Inhibition of HDAC1 (unknown origin) after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Inhibition of HDAC6 (unknown origin) after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human HDAC1 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate readerMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of human HDAC4 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate readerMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of mouse HDAC6 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate readerMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 50005711
ITC DataΔG°: -8.60kcal/mole −TΔS°: 0.0179kcal/mole ΔH°: -8.80kcal/mole logk: 3.36E+6
pH: 7.5 T: -248.15°C
pH: 7.5 T: -248.15°C