BDBM50009859 (+-)-2-(p-isobutylphenyl)propionic acid::(+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid::(+-)-ibuprofen::(+-)-p-isobutylhydratropic acid::(4-isobutylphenyl)-alpha-methylacetic acid::(RS)-ibuprofen::2-(4-isobutylphenyl)propanoic acid::2-[4-(2-methylpropyl)phenyl]propanoic acid::4-isobutylhydratropic acid::Advil::Brufen::CHEMBL521::IBUPROFEN LYSINE::Ibuprofen::Ibuprofen (1)::Motrin::alpha-(4-isobutylphenyl)propionic acid::alpha-(p-isobutylphenyl)propionic acid

SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI Key InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N

Data  22 KI  138 IC50  2 Kd

PDB links: 14 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50009859   

TargetProstaglandin G/H synthase 1/2(RAT)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50:  600nMAssay Description:Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed