BDBM50012477 1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester::1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester(Carefentanil)::CARFENTANIL::CHEMBL290429::Carfentanil1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester::US20230399418, Compound Carfentanil

SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccccc2)CC1)C(=O)OC

InChI Key InChIKey=YDSDEBIZUNNPOB-UHFFFAOYSA-N

Data  10 KI  2 IC50  1 Kd  1 EC50  1 Koff  1 Kon

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50012477   

TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  0.0240nMAssay Description:Binding affinity against Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  0.0240nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]DSLET from delta opioid receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity against Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  9nMAssay Description:Opioid receptor kappa 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  43nMAssay Description:Binding affinity against Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  92nMAssay Description:Opioid receptor kappa 1 apparent binding constant from guinea pig cerebellum using [3H]diprenorphine binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataEC50:  0.00490nMAssay Description:Agonist activity at human MOR expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins and measured after 1 hr by Eu-cAMP tracer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOpioid-binding protein/cell adhesion molecule(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKd:  0.0718nM Kon:  0.000243M-1s-1 Koff:  3.39E+6s-1Assay Description:The direct binding kinetics of JBZ-4 to fentanyl and related analogues was thoroughly characterized by surface plasmon resonance (SPR) single cycle k...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In DepthDetails US Patent
TargetMu-type opioid receptor(GUINEA PIG)
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataIC50:  0.0190nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataIC50:  17nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed