BDBM50012957 1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea::1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea::5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide::5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide::CHEMBL472::GLYBURIDE::Glibenclamide::US20230348371, Compound 5

SMILES COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1

InChI Key InChIKey=ZNNLBTZKUZBEKO-UHFFFAOYSA-N

Data  8 KI  36 IC50  1 EC50

PDB links: 14 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50012957   

TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  130nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  660nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 6(Rattus norvegicus)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  1.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  1.67E+3nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Rattus norvegicus)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  6.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in membrane vesicles from Bsep-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 15 member 2(Rattus norvegicus)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  7.80E+3nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 15 member 1(Rattus norvegicus)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  2.50E+4nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
King'S College Hospital

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  2.75E+4nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake(Glibenclamide 30uM, 50 % of control) in membrane vesicles prepared from High Five cells infected wi...More data for this Ligand-Target Pair