BDBM50015214 6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-methylbutyl)amine::6-chloro-N-(5-(diethylamino)pentan-2-yl)-2-methoxyacridin-9-amine::CHEMBL7568::N'-(6-chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine::N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine::N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine (Mepacrine)::N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine ; (mepacrine)::N-(4-Hydroxy-phenyl)-acetamide::atabrine::cid_237::quinacrine

SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12

InChI Key InChIKey=GPKJTRJOBQGKQK-UHFFFAOYSA-N

Data  4 KI  26 IC50  2 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50015214   

TargetProstaglandin G/H synthase 1/2(Sheep)
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of ovine seminal vesicle prostaglandin synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetPhospholipase A2, membrane associated(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 3.20E+8nMAssay Description:In vitro inhibition of rat secretory Phospholipase A2 (group II).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 7.60E+7nMAssay Description:In vitro inhibition of human recombinant secretory Phospholipase A2 (group II).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMajor prion protein(Human)
Institut F£R Molekularbiologie Und Biophysik

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataEC50:  300nMAssay Description:Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1/2(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 3.26E+4nMAssay Description:Tested for its inhibitory activity against PGS (prostaglandin synthetase).More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Strasbourg 1 University

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataEC50:  1.44E+4nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-CEM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcidic phospholipase A2 2(Indian cobra)
Universitat De Val£Ncia

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 2.15E+6nMAssay Description:Inhibition of Naja Naja PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistidine-rich protein PFHRP-II(malaria parasite P. falciparum)
Kyoto Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 2.92E+5nMAssay Description:Inhibition of Tween 20-induced beta-hematin formation by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataEC50: >5.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 5.00E+4nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclic GMP-AMP synthase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of cGAS (unknown origin) incubated for 1 hr by Typhoon imaging system analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclic GMP-AMP synthase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of cGAS in human THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTrypanothione reductase(Leishmania infantum)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of recombinant His-tagged Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli BL21 (DE3) using TS2 and NADPH as...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 95nMAssay Description:Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of rat basophilic leukemia cell 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCystic fibrosis transmembrane conductance regulator(Human)
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.99E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetDNA-directed RNA polymerase subunit beta'(Escherichia coli (strain K12))
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Escherichia coli DNA-primed RNA polymerase activity using [8-14C]ATP by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibitory concentration against trypanothione reductase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory concentration against human Glutathione reductase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Rat)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcidic phospholipase A2 2(Indian cobra)
Universitat De Val£Ncia

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 2.16E+6nMAssay Description:Inhibition of snake venom phospholipase A2 assessed as oxygen consumption for 3 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldehyde oxidase 1(Rabbit)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rabbit aldehyde oxidaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldehyde oxidase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human aldehyde oxidaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Horse)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocholine iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRiboflavin-binding protein(Chicken)
Calvin College

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataKd:  264nMpH: 7.4Assay Description:Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calori...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.00E+5nMAssay Description:Tested for its inhibitory activity against Phospholipase A2 (PLA2)More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.30E+5nMAssay Description:Tested for its inhibitory activity against 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetPhospholipase A2(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against polymorphonuclear cell phospholipase-A2 in ratMore data for this Ligand-Target Pair
In DepthDetails Article

TargetRiboflavin-binding protein(Chicken)
Calvin College

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataKi:  6.70E+3nMAssay Description:Competitive inhibition of chicken riboflavin binding protein by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataKi:  1.90E+4nMAssay Description:The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plotsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed