BDBM50017268 CHEMBL3287723::US10099993, Compound 96

SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O

InChI Key InChIKey=AOYJKNKRKBOUAP-UHFFFAOYSA-N

Data  2 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50017268   

TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017268(CHEMBL3287723 | US10099993, Compound 96)
Affinity DataEC50:  151nMAssay Description:Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017268(CHEMBL3287723 | US10099993, Compound 96)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human histamine H2 receptor at 10 uM by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017268(CHEMBL3287723 | US10099993, Compound 96)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human histamine H4 receptor at 10 uM by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50017268(CHEMBL3287723 | US10099993, Compound 96)
Affinity DataEC50:  1.07E+3nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50017268(CHEMBL3287723 | US10099993, Compound 96)
Affinity DataEC50:  184nMpH: 7.3 T: 2°CAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50017268(CHEMBL3287723 | US10099993, Compound 96)
Affinity DataEC50:  151nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50017268(CHEMBL3287723 | US10099993, Compound 96)
Affinity DataEC50:  955nMpH: 7.3 T: 2°CAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50017268(CHEMBL3287723 | US10099993, Compound 96)
Affinity DataEC50:  184nMAssay Description:Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed