BDBM50017701 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one::3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one::CHEMBL117785::TETRABENAZINE::Tetrabenazine (TBZ)

SMILES COc1cc2CCN3CC(CC(C)C)C(=O)CC3c2cc1OC

InChI Key InChIKey=MKJIEFSOBYUXJB-UHFFFAOYSA-N

Data  5 KI  7 IC50  11 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50017701   

TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017701BDBM50017701(3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-py...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017701BDBM50017701(3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-py...)
Affinity DataKi:  54nMAssay Description:Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed