BDBM50020587 CHEMBL3290185

SMILES COc1cc(\C=C\C(=O)CC(=O)\C=C\c2cc(F)c(O)c(OC)c2)cc(F)c1O

InChI Key InChIKey=WYTDPUYUSRWWCD-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50020587   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020587(CHEMBL3290185)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020587(CHEMBL3290185)
Affinity DataEC50:  8.60E+3nMAssay Description:Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinoneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020587(CHEMBL3290185)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of mPGES1-mediated PGE2 production in microsomes of IL-1beta stimulated human A549 cells preincubated for 15 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020587(CHEMBL3290185)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020587(CHEMBL3290185)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020587(CHEMBL3290185)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of COX1-mediated PGE2 production in human platelets assessed as formation of 12-HHT using arachidonic acid as substrate preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed