BDBM50021365 CHEMBL407641::Mezilamine::[4-Chloro-6-(4-methyl-piperazin-1-yl)-5-methylsulfanyl-pyrimidin-2-yl]-methyl-amine

SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1

InChI Key InChIKey=ITYXRJDDBZMFAY-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50021365   

TargetD(2) dopamine receptor(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50021365(CHEMBL407641 | Mezilamine | [4-Chloro-6-(4-methyl-...)
Affinity DataKi:  5.40nMAssay Description:Binding affinity of the compound to Dopamine receptor D2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021365(CHEMBL407641 | Mezilamine | [4-Chloro-6-(4-methyl-...)
Affinity DataKi:  9nMAssay Description:In vitro binding affinity was measured as the inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor of rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021365(CHEMBL407641 | Mezilamine | [4-Chloro-6-(4-methyl-...)
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]idazoxan binding to alpha-2 adrenergic receptor of rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50021365(CHEMBL407641 | Mezilamine | [4-Chloro-6-(4-methyl-...)
Affinity DataKi:  40nMAssay Description:In vitro ability to displace [3H]spiroperidol from rat dopamine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50021365(CHEMBL407641 | Mezilamine | [4-Chloro-6-(4-methyl-...)
Affinity DataKi:  40nMAssay Description:In vitro binding affinity to Dopamine receptors of rat striatal membranes by [3H]spiroperidol displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50021365(CHEMBL407641 | Mezilamine | [4-Chloro-6-(4-methyl-...)
Affinity DataKi:  91nMAssay Description:In vitro binding affinity was measured as the inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50021365(CHEMBL407641 | Mezilamine | [4-Chloro-6-(4-methyl-...)
Affinity DataKi:  430nMAssay Description:Binding affinity of the compound to 5-hydroxytryptamine 1A receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50021365(CHEMBL407641 | Mezilamine | [4-Chloro-6-(4-methyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of the compound to Dopamine receptor D4 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed