BDBM50021365 CHEMBL407641::Mezilamine::[4-Chloro-6-(4-methyl-piperazin-1-yl)-5-methylsulfanyl-pyrimidin-2-yl]-methyl-amine
SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1
InChI Key InChIKey=ITYXRJDDBZMFAY-UHFFFAOYSA-N
Data 8 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50021365
Affinity DataKi: 5.40nMAssay Description:Binding affinity of the compound to Dopamine receptor D2 was determinedMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 9nMAssay Description:In vitro binding affinity was measured as the inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor of rat cortical membranesMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of [3H]idazoxan binding to alpha-2 adrenergic receptor of rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:In vitro ability to displace [3H]spiroperidol from rat dopamine receptorMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:In vitro binding affinity to Dopamine receptors of rat striatal membranes by [3H]spiroperidol displacement.More data for this Ligand-Target Pair
Affinity DataKi: 91nMAssay Description:In vitro binding affinity was measured as the inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat cortical membranesMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Pharmaceuticals
Curated by ChEMBL
Sumitomo Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 430nMAssay Description:Binding affinity of the compound to 5-hydroxytryptamine 1A receptor was determinedMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of the compound to Dopamine receptor D4 was determinedMore data for this Ligand-Target Pair