BDBM50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid
SMILES OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O
InChI Key InChIKey=HZZVJAQRINQKSD-PBFISZAISA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 79 hits for monomerid = 50021959
Affinity DataKi: 800nMAssay Description:Inhibition constant (Ki) for TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nM IC50: 100nMpH: 7.4Assay Description:Steady state kinetics were performed on an Agilent 8453 diode array spectrophotometer in 10 mM phosphate-buffered saline (pH 7.4). IC50, defined as t...More data for this Ligand-Target Pair
Affinity DataKi: 6.30E+3nMpH: 7.2Assay Description:Steady state kinetics were performed on an Agilent 8453 diode array spectrophotometer in sodium phosphate buffer (50 mM, pH 7.2) and a 1 cm pathlengt...More data for this Ligand-Target Pair
Affinity DataKi: 1.10E+4nMAssay Description:Inhibition of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by competitive assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.54E+4nMAssay Description:Inhibition of Klebsiella pneumoniae beta-lactamase SHV-105More data for this Ligand-Target Pair
Affinity DataKi: 1.08E+5nMAssay Description:Inhibition of Citrobacter freundii beta-lactamase SHV-95More data for this Ligand-Target Pair
Affinity DataKi: 2.27E+5nMAssay Description:Inhibition of Acinetobacter baumannii beta-lactamase SHV-48More data for this Ligand-Target Pair
Affinity DataKi: 2.29E+5nMAssay Description:Inhibition of Klebsiella pneumoniae beta-lactamase SHV-89More data for this Ligand-Target Pair
Affinity DataIC50: 95.4nMAssay Description:Inhibition of Proteus mirabilis C889 beta-lactamase assessed as inhibition of nitrocefin hydrolysis preincubated for 5 mins by microtiter plate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of Staphylococcus aureus Russell beta-lactamase assessed as inhibition of nitrocefin hydrolysis pre-incubated for 5 mins by microtiter pla...More data for this Ligand-Target Pair
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3.71E+6nMAssay Description:Inhibition of Pseudomonas aeruginosa A beta-lactamase assessed as inhibition of nitrocefin hydrolysis preincubated for 5 mins by microtiter plate ass...More data for this Ligand-Target Pair
Affinity DataIC50: 7.78E+5nMAssay Description:Inhibition of Enterobacter cloacae P99 beta-lactamase assessed as inhibition of nitrocefin hydrolysis pre-incubated for 5 mins by microtiter plate as...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of Pseudomonas luteola LAM Beta-lactamase LUT-1More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of Pseudomonas aeruginosa 531 beta-lactamase BEL-2More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of Pseudomonas aeruginosa 51170 beta-lactamase BEL-1More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+5nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 30.3nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 29.5nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Compound was evaluated for beta-lactamase inhibition activity of Escherichia coli after 15 min of preincubation with the enzyme at 37 degree CMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was evaluated for beta-lactamase inhibition activity of Enterobacter cloacae after 15 min of preincubation with the enzyme at 37 degree CMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibitory activity against Beta-lactamase type OXA1 (penicillinase) from E. coli OXA1 using ampicillin (40 uM) as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibitory activity against Penicillinase from Staphylococcus aureus TH-14 using piperacillin (40 uM) as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibitory activity against Beta-lactamase type TEM2 (penicillinase) from E. coli TEM2 using penicillin G (40 uM) as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against Escherichia coli TEM-3 Beta-lactamaseMore data for this Ligand-Target Pair
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Deacylation of 18SH Beta-lactamase of Pseudomonas aeruginosaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 7.28E+4nMAssay Description:Inhibition of Serratia fonticola UTAD54 SFC1 beta lactamase expressed in Escherichia coli BL21(DE3) by SDS-PAGEMore data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of Escherichia coli DH5alpha beta-lactamase TEM-158More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of Escherichia coli DH5alpha beta-lactamase TEM-1More data for this Ligand-Target Pair
TargetBeta-lactamase(Escherichia coli)
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of Escherichia coli CTX-M-15More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of Escherichia coli beta-lactamase ACC4More data for this Ligand-Target Pair
TargetCarbapenem-hydrolyzing beta-lactamase KPC(Klebsiella pneumoniae)
Bicetre Hospital
Curated by ChEMBL
Bicetre Hospital
Curated by ChEMBL
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of carbapenem-resistant Klebsiella pneumoniae carbepenem-hydrolyzing beta-lactamase KPC-1More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as reduction in nitrocefin hydrolysis by...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1More data for this Ligand-Target Pair
TargetBeta-lactamase(Klebsiella pneumoniae)
National Institute of Health Dr. Ricardo Jorge Av. Padre Cruz
Curated by ChEMBL
National Institute of Health Dr. Ricardo Jorge Av. Padre Cruz
Curated by ChEMBL
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-72More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-55More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of Pseudomonas aeruginosa GES-13 beta lactamaseMore data for this Ligand-Target Pair
TargetBeta-lactamase(Acinetobacter genomosp. 3)
Complejo Hospitalario Universitario Juan Canalejo-INIBIC
Curated by ChEMBL
Complejo Hospitalario Universitario Juan Canalejo-INIBIC
Curated by ChEMBL
Affinity DataIC50: 2.36E+5nMAssay Description:Inhibition of Acinetobacter genomosp. 3 isolate 65 ADC-14More data for this Ligand-Target Pair
TargetBeta-lactamase(Acinetobacter genomosp. 3)
Complejo Hospitalario Universitario Juan Canalejo-INIBIC
Curated by ChEMBL
Complejo Hospitalario Universitario Juan Canalejo-INIBIC
Curated by ChEMBL
Affinity DataIC50: 1.46E+6nMAssay Description:Inhibition of Acinetobacter genomosp. 3 isolate 103 ADC-16More data for this Ligand-Target Pair
TargetBeta-lactamase(Acinetobacter genomosp. 3)
Complejo Hospitalario Universitario Juan Canalejo-INIBIC
Curated by ChEMBL
Complejo Hospitalario Universitario Juan Canalejo-INIBIC
Curated by ChEMBL
Affinity DataIC50: 1.93E+6nMAssay Description:Inhibition of Acinetobacter genomosp. 3 isolate 195 ADC-18More data for this Ligand-Target Pair
TargetBeta-lactamase(Salmonella enterica subsp. enterica serovar Westha...)
Centre National de R£f£rence des Salmonella
Curated by ChEMBL
Centre National de R£f£rence des Salmonella
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+6nMAssay Description:Binding affinity to Acinetobacter baumannii ADC-33 beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+6nMAssay Description:Binding affinity to Acinetobacter baumannii ADC-11 beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase P99 assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubationMore data for this Ligand-Target Pair
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa beta-lactamase AmpC assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubationMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae SC 12368 E-2More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibitory activity against beta-Lactamase enzyme derived from Escherichia coli WC3310 TEM-2More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of hydrolysis of nitrocephin after 5 min pre-incubation with P99 beta-lactamases (class C)More data for this Ligand-Target Pair