BDBM50026636 17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic acid methyl ester::CHEMBL10347::RAUWOLSCINE HYDROCHLORIDE::alpha-yohimbine::corynanthidine::isoyohimbine::mesoyohimbine::methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate::methyl 17alpha-hydroxy-20alpha-yohimban-16beta-carboxylate::rauwolscine
SMILES COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
InChI Key InChIKey=BLGXFZZNTVWLAY-DIRVCLHFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 50026636
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Binding affinity against Alpha-1B adrenergic receptor from hamster clones.More data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Compound was evaluated for inhibition of binding of [3H]-rauwolscine to Alpha-2 adrenergic receptor in bovine pinealMore data for this Ligand-Target Pair
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 3.5nMAssay Description:Binding affinity against Alpha-1D adrenergic receptor, from human clones.More data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in rat cerebral cortex using [3H]rauwolscineMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity by its ability to displace [3H]rauwolscine radioligand from Alpha-2 adrenergic receptor on rat cerebral cortexMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity towards alpha-2 adrenergic receptor in rat cortex membrane using [3H]rauwolscine radioligandMore data for this Ligand-Target Pair
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 4.60nMAssay Description:The compound was tested for binding affinity against Alpha-1B adrenergic receptor , from human clones.More data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 4.60nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 4.70nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(GUINEA PIG)
Smith Kline & French Laboratories
Curated by PDSP Ki Database
Smith Kline & French Laboratories
Curated by PDSP Ki Database
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataKi: 7.10nMAssay Description:Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membraneMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataKi: 7.10nMAssay Description:Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligandMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(GUINEA PIG)
Smith Kline & French Laboratories
Curated by PDSP Ki Database
Smith Kline & French Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 18nMAssay Description:Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]-clonidine as the radioligandMore data for this Ligand-Target Pair
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 35nMAssay Description:Binding affinity against Alpha-1D adrenergic receptor, from rat clones.More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Inhibition of [3H]nitrendipine binding to membrane homogenates of rat cardiac muscle.More data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Smith Kline & French Laboratories
Curated by PDSP Ki Database
Smith Kline & French Laboratories
Curated by PDSP Ki Database
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataKi: 81nMAssay Description:Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligandMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataKi: 149nMAssay Description:Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat brain membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Syntex Research
Curated by ChEMBL
Syntex Research
Curated by ChEMBL
Affinity DataKi: 316nMAssay Description:Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membraneMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Smith Kline & French Laboratories
Curated by PDSP Ki Database
Smith Kline & French Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 940nMAssay Description:Binding activity against alpha-1 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 940nMAssay Description:Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(RABBIT)
Smith Kline & French Laboratories
Curated by PDSP Ki Database
Smith Kline & French Laboratories
Curated by PDSP Ki Database
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 1.32E+3nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(RABBIT)
Smith Kline & French Laboratories
Curated by PDSP Ki Database
Smith Kline & French Laboratories
Curated by PDSP Ki Database
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 2.27E+3nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1B adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(RABBIT)
Smith Kline & French Laboratories
Curated by PDSP Ki Database
Smith Kline & French Laboratories
Curated by PDSP Ki Database
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 4.40E+3nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1A adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKd: 13.8nMAssay Description:In vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidineMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 165nMAssay Description:Inhibition of specific [3H]-clonidine binding (0.4 nM) to rat brain membranes alpha2 adrenoceptorMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Syntex Research
Curated by ChEMBL
Syntex Research
Curated by ChEMBL
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 8.38E+3nMAssay Description:Inhibition of horse BChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of human BChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:In vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidineMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human recombinant alpha2C adrenoceptor assessed as inhibition of epinephrine-induced cAMP accumulationMore data for this Ligand-Target Pair