BDBM50028197 2-(difluoromethyl)ornithine::CHEMBL830::EFLORNITHINE

SMILES NCCCC(N)(C(F)F)C(O)=O

InChI Key InChIKey=VLCYCQAOQCDTCN-UHFFFAOYSA-N

Data  1 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50028197   

TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitochondrial 2-oxodicarboxylate carrier(Homo sapiens)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50:  2.52E+5nMAssay Description:Inhibition of ODC (unknown origin) expressed in Escherichia coli after 30 mins in presence of [1-14C] L-ornithine by liquid scintillation counter ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human mitochondrial HSP60/HSP10-ATPase activity expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Escherichia coli GroEL/GroES-ATPase activity expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human mitochondrial HSP60/HSP10 expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Escherichia coli GroEL/GroES expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed